Golovkin promoter Tom Loeffler announced the HBO matchup on Tuesday.
The 32-year-old Golovkin (30-0, 27 KOs) will make his long-anticipated West Coast debut at the outdoor StubHub Center south of Los Angeles against Rubio, a Mexican veteran who has won 16 of his last 17 bouts.
The Kazakh-born Golovkin lives in Germany, but trains in Big Bear, California, with Abel Sanchez. His five previous U.S. fights were on the East Coast, including his American debut in September 2012.
''His growing popularity across the country compels us to bring this highly anticipated fight to the StubHub Center, which has hosted so many exciting boxing events in recent years,'' said Loeffler, the managing director of K2 Promotions.
Although Golovkin has never fought in California, he is already popular among the West Coast's savvy fight fans. He has been mobbed by autograph-seekers and well-wishers while attending fights at the outdoor ring or the nearby Forum in recent months.