Worldwide Study Triples Genetic Risk Factors for Stroke
WASHINGTON (Dispatches)-The largest genetic study of stroke to date triples the number of known genetic risk factors for the disease and also should enable researchers to find novel treatments for dementia.
A landmark international study of DNA samples from 520,000 individuals worldwide -- including 67,000 affected individuals -- identified 22 new genetic risk factors for stroke.
Previously, only 10 genetic risk factors had been identified for stroke.
Sudha Seshadri, M.D., of University of Texas, said the identification of genetic regions that are strongly correlated to stroke will increase potential targets for stroke drug development.
A chief aim of the research is to identify novel risk factors and groundbreaking treatments for dementia, and the study provides excellent fodder for investigations along that line, Dr. Seshadri said.
"Understanding these newly identified risk factors for stroke should also enable us to find novel treatments for dementia," Dr. Seshadri said. "Vascular disease in the brain -- a series of strokes -- can lead to dementia."
The study identified novel genetic risk factors for all major subtypes of ischemic stroke. An ischemic stroke occurs when a blood vessel supplying the brain is blocked. About 80 percent of strokes are ischemic.
The study found the largest correlation between genetic risk factors and blood pressure. Hypertension is a major risk factor for stroke.
Vascular health is important for brain function. The brain does not store energy and requires a constant supply of blood and oxygen, as well as blood glucose. "Any disruption can lead to cognitive problems," Dr. Seshadri said. "The most obvious example of that is stroke. There is a deficit in the blood supply and that is associated with very obvious changes in cognitive function."
A landmark international study of DNA samples from 520,000 individuals worldwide -- including 67,000 affected individuals -- identified 22 new genetic risk factors for stroke.
Previously, only 10 genetic risk factors had been identified for stroke.
Sudha Seshadri, M.D., of University of Texas, said the identification of genetic regions that are strongly correlated to stroke will increase potential targets for stroke drug development.
A chief aim of the research is to identify novel risk factors and groundbreaking treatments for dementia, and the study provides excellent fodder for investigations along that line, Dr. Seshadri said.
"Understanding these newly identified risk factors for stroke should also enable us to find novel treatments for dementia," Dr. Seshadri said. "Vascular disease in the brain -- a series of strokes -- can lead to dementia."
The study identified novel genetic risk factors for all major subtypes of ischemic stroke. An ischemic stroke occurs when a blood vessel supplying the brain is blocked. About 80 percent of strokes are ischemic.
The study found the largest correlation between genetic risk factors and blood pressure. Hypertension is a major risk factor for stroke.
Vascular health is important for brain function. The brain does not store energy and requires a constant supply of blood and oxygen, as well as blood glucose. "Any disruption can lead to cognitive problems," Dr. Seshadri said. "The most obvious example of that is stroke. There is a deficit in the blood supply and that is associated with very obvious changes in cognitive function."