WASHINGTON (Dispatches) Long-term use of popular drugs commonly used to treat heartburn, acid reflux and ulcers - could lead to kidney damage and severe kidney disease, say researchers.
They reported their findings in the Journal of the American Society of Nephrology.
The researchers came to this conclusion after analyzing large collections of patient data held in the Department of Veterans Affairs (VA) national databases.
Proton pump inhibitors (PPIs) reduce the stomach acid made by glands in the lining of the stomach. This is not the same as antacids, which reduce excess acid after it enters the stomach.
They are commonly used to relieve symptoms of acid refluxor gastroesophageal reflux disease (GERD) - a condition where food or liquid from the stomach moves up into the esophagus or food pipe.
PPIs are also used to treat peptic or stomach ulcers and damage to the lower esophagus caused by acid reflux. There are many names and brands of PPIs. Most work equally as well, although side effects may vary. Some are also available over the counter - that is, without a prescription.
Common types of PPI include omeprazole (brand name Prilosec, also available over the counter), esomeprazole (Nexium), lansoprazole (Prevacid), rabeprazole (AcipHex), pantoprazole (Protonix), dexlansoprazole (Dexilant) and Zegerid (omeprazole with sodium bicarbonate).