The new airstrikes, carried out in the Syrian city of Raqa on Saturday and Sunday, wounded dozens of others, said the so-called Syrian Observatory for Human Rights.
"The significant air strikes tonight were executed to deny Daesh (IS) the ability to move military capabilities throughout Syria and into Iraq," spokesman Lieutenant Colonel Thomas Gilleran said.
"This was one of the largest deliberate engagements we have conducted to date in Syria and it will have debilitating effects on Daesh's ability to move from Raqa."
Gilleran said that coalition forces were able to strike multiple targets "successfully”, destroying ISIL structures and transit routes.
He added that the terrorists’ "freedom of movement” was severely restricted by the air raids.
The US and its allies have been conducting air strikes on the ISIL terrorists, who currently control parts of Syria and neighboring Iraq.
The group has carried out crimes such as public decapitations and crucifixions against all ethnic and religious groups, including Shias, Sunnis, Kurds, Christians, Izadi Kurds and others.
Meanwhile, at least two people have been killed and over a dozen others injured in mortar attacks by foreign-backed Takfiri terrorists in and around the Syrian capital, Damascus.
A civilian was killed and nine others sustained injuries on Saturday after 9 shells fired by the terrorists hit several residential neighborhoods in Damascus, Syria’s official news agency, SANA, quoted an unnamed source with the Damascus Police Command as saying.
The source added that at least three cars were set afire and material damage was caused to a number of houses and shops in the attack.
The Takfiri terrorists positioned in the Eastern Ghouta region of the Syrian province of Rif Dimashq fired the mortar shells.
In a separate development, at least a woman was killed and nine others were injured after rockets fired by terrorists landed in the residential areas of al-Kashkoul and al-Kabbas near Damascus.
Cities and towns across Syria have been hit by bomb attacks, mortar and rocket fire by Takfiri terrorists since conflict broke out in the Arab country more than four years ago. More than 230,000 people have since been killed in Syria.
Backed by Western powers and their regional allies, including Saudi Arabia, Qatar and Turkey, the terrorists have forced over 3.8 million Syrians to take refuge in neighboring countries, namely Jordan and Lebanon.