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News ID: 89187
Publish Date : 14 April 2021 - 21:13

Oral Drug May Prevent Certain Skin Cancers

WASHINGTON (Dispatches) ---   New research suggests that an oral drug currently used in the clinical setting to treat neuromuscular diseases could also help prevent a common form of skin cancer caused by damage from ultraviolet-B (UVB) radiation from the sun.
Researchers at The Ohio State University Comprehensive Cancer Center report data showing that the neurotransmitter/neurohormone dopamine, by activating its D2 receptors, can stop the development and progression of certain UVB-induced precancerous squamous skin cancers. Researchers also describe the molecular sequence of events that leads to cancer suppression.
The study suggests that a commonly used drug that activates specific dopamine receptors could help reduce squamous cell skin cancer recurrence and possibly even prevent the disease entirely.
The  drug  is already being used in clinical settings and is relatively inexpensive.  Senior author Sujit Basu, MD, PhD, says preliminary results in animal models are very promising and worthy of immediate further investigation through phase I human studies.