Government spokesperson and Communication Minister Issa Tchiroma Bakary made the announcement on Monday.
"We are on the way to close the border with Nigeria because of Ebola,” the Cameroonian official said.
Bakary did not release a specific date when the border would be closed.
So far, there have been no reports of Ebola cases in Cameroon, which shares a 2,000-kilometer border with Nigeria.
This comes as an information sharing and working session on Ebola was held in the African Union headquarters in the Ethiopian capital, Addis Ababa.
The World Health Organization (WHO) has also called on Ebola-affected countries to begin exit scanning for all passengers departing international airports, seaports, and ground crossings.
The virus spreads through direct contact with infected blood, feces or sweat. It can also be spread through sexual contact or the unprotected handling of contaminated corpses.
Ebola was first discovered in the Democratic Republic of Congo in 1976 in an outbreak that killed 280 people. It remains one of the world’s most virulent diseases, which kills between 25 to 90 percent of those who fall sick.
According to WHO, the virus has already killed at least 1,145 people in African countries, including in Liberia, Sierra Leone, Guinea, and Nigeria.